Book Review, Antifungal Azoles
نویسندگان
چکیده
منابع مشابه
Antifungal azoles: old and new.
Management of fungal infections is complex with increasing choice of antifungals. Mortality and morbidity are significant despite treatment. Azoles are commonly used compounds which inhibit fungal lanosterol 14 demethylase, thereby depleting ergosterol in the fungal cell membrane with the accumulation of lanosterol precursors. Imidazoles (miconazole, ketoconazole, clotrimazole) are used in topi...
متن کاملAbnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles
Fungi transcriptionally upregulate expression of azole efflux pumps and ergosterol biosynthesis pathway genes when exposed to antifungal agents that target ergosterol biosynthesis. To date, these transcriptional responses have been shown to be dependent on the presence of the azoles and/or depletion of ergosterol. Using an inducible promoter to regulate Neurospora crassa erg11, which encodes th...
متن کاملChloroquine sensitizes biofilms of Candida albicans to antifungal azoles.
Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored. In this study, potential of chloroquine to be a partner drug in combination with four antifungal agents, namely fluconazole, voriconazole, amphotericin B, and caspofung...
متن کاملAntifungal azoles – new antidote for chronic pelvic pain?
Cent Eur J Urol 2013; 66: 200-201 DOI: 10.5173/ceju.2013.02.art22 Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a poorly–defined condition or a group of conditions in which chronic pain in the genital area and pain during prostate palpation are the two most common features. Causative treatment is rarely available since in most cases the etiology in unknown. Paradoxically, long–t...
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ژورنال
عنوان ژورنال: Synthesis
سال: 1998
ISSN: 0039-7881,1437-210X
DOI: 10.1055/s-1998-4531